DeFries-Fulker multiple regression analysis of sibship QTL data: a SAS®macro
نویسندگان
چکیده
A SAS macro package for performing multipoint QTL mapping using the DeFries-Fulker multiple regression method is presented.
منابع مشابه
Multiple regression analysis of twin data obtained from selected samples.
The multiple regression analysis of twin data in which a cotwin's score is predicted from that of a proband (the member of a twin pair selected because of a deviant score) and the coefficient of relationship provides a powerful test of genetic etiology (DeFries and Fulker: Behav Genet 15:467-473, 1985). Moreover, when an augmented model containing an interaction term is fitted to the same data ...
متن کاملEvidence for linkage and association with reading disability on 6p21.3-22.
Reading disability (RD), or dyslexia, is a common heterogeneous syndrome with a large genetic component. Several studies have consistently found evidence for a quantitative-trait locus (QTL) within the 17 Mb (14.9 cM) that span D6S109 and D6S291 on chromosome 6p21.3-22. To characterize further linkage to the QTL, to define more accurately the location and the effect size, and to identify a peak...
متن کاملMultiple regression analysis of twin data: etiology of deviant scores versus individual differences.
The multiple regression analysis of twin data in which a cotwin's score is predicted from a proband's score and the coefficient of relationship (the basic model) provides a statistically powerful test of genetic etiology. When an augmented model that also contains an interaction term is fitted to the same data set, direct estimates of heritability (h2) and the proportion of variance due to shar...
متن کاملMultiple regression analysis of twin data.
A multiple regression model for the analysis o f twin data is described in which a cotwin's score is predicted from a proband's score and the coefficient o f relationship (R = 1.0 and 0.5 for identical and fraternal twin pairs, respectively). This model is especially appropriate for the analysis o f data on twins in which one member o f each pair has been selected because o f a deviant score, e...
متن کاملDF-analyses of heritability with double-entry twin data: asymptotic standard errors and efficient estimation.
In this paper we establish the asymptotic distribution of DeFries Fulker (1985) regression estimates for heritability and shared environmental influences with double-entry twin data. A simple formula to estimate the covariance matrix of the coefficients in DF-regressions is provided, and applications to simulated data and Danish twin data show that this method can substantially increase the sta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Bioinformatics
دوره 17 4 شماره
صفحات -
تاریخ انتشار 2001